Ziboh, V. A., Naguwa, S., Vang, K., Wineinger, J., Morrissey, B. M., Watnik, M., and Gershwin, M. E. Suppression of leukotriene B4 generation by ex-vivo neutrophils isolated from asthma patients on dietary supplementation with gammalinolenic acid-containing borage oil: possible implication in asthma. J Hepatol 2003;39:437-46. Oral administration of gammalinolenic acid, an unsaturated fatty acid with anti-inflammatory properties, modulates interleukin-1beta production by human monocytes. Borage has been used alone and in combination with fish oil for the treatment of rheumatoid arthritis, skin disorders, and bone weakening, although clinical evidence to support these uses is limited. Borage supplements may cause mild side effects, including digestive problems. It’s widely available as an oil, softgel, or herbal tea. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. DeLuca P, Rothman D, Zurier RB. J Clin Immunol 2002;22:83-91. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. CONDITIONS OF USE AND IMPORTANT INFORMATION: J Biochem Biophys Methods 2002;53:45-9. What factors influenced or will influence your purchase? Available at: https://www.cfsan.fda.gov/~dms/dspltr06.html. Additionally, one study in 74 people even observed that taking a borage oil supplement for 18 months, with or without fish oil, reduced symptoms of rheumatoid arthritis, an inflammatory disorder (3). Br J Dermatol 2000;143(1):200-201. There is some evidence that borage seed oil, when taken by mouth in combination with eicosapentaenoic acid (EPA), might reduce the number of days spent in the intensive care unit (ICU) and the length of time a breathing machine is needed by patients with acute respiratory distress syndrome (ARDS). View abstract. Before applying, be sure to dilute borage oil with a carrier oil, such as coconut or avocado oil, to prevent skin irritation. GLA is an omega-6 fatty acid found in evening primrose oil. View abstract. There are seven types of eczema. J Nat Prod 1984;47:747-8. Martens-Lobenhoffer, J. and Meyer, F. P. Pharmacokinetic data of gamma-linolenic acid in healthy volunteers after the administration of evening primrose oil (Epogam). J Ren Nutr 2005;15(3):318-331. Lipids 2001;36(6):555-566. View abstract. The effect of borage oil consumption on the composition of individual phospholipids in human platelets. Borage has been linked to a number of potential health benefits. Dietary gamma-linolenic acid lowers blood pressure and alters aortic reactivity and cholesterol metabolism in hypertension. Growth and development in premature infants. Asthma. Botanical lipids: effects on inflammation, immune responses, and rheumatoid arthritis. Belch J, Hill A. View abstract. Leventhal LJ, Boyce EG, Zurier RB. Pharmazie 1995;50:83-98. Some NSAIDs include ibuprofen (Advil, Motrin, Nuprin, others), indomethacin (Indocin), naproxen (Aleve, Anaprox, Naprelan, Naprosyn), piroxicam (Feldene), aspirin, and others. Meanwhile, the seeds are used to make borage oil, which is usually applied topically to the hair and skin. View abstract. Meta-analysis of placebo-controlled studies of the efficacy of Epogam in the treatment of atopic eczema. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. Holman CP and Bell AF. 1997;209(3):100-104. Henz BM. It seems to heal the condition within 1 to 3 weeks. According to one test-tube and animal study, borage seed oil was found to protect against oxidative cell damage, which could contribute to inflammation (7, 8). Available for Android and iOS devices. Many people have trouble distinguishing the differences between psoriasis and eczema, but it's important to…, Severe eczema can be difficult to manage. View abstract. Bandoniene D, Murkovic M. The detection of radical scavenging compounds in crude extract of borage (Borago officinalis L.) by using an on-line HPLC-DPPH method. The fresh plant has a salty flavor and a cucumber-like odor. If you’re wondering if borage oil is really worth all the hype, read on to learn about the potential benefits as well as the drawbacks. Information from this source is evidence-based and objective, and without commercial influence. 2016;2016:9130979. 1989;3(2):111-116. Kalantar-Zadeh, K., Braglia, A., Chow, J., Kwon, O., Kuwae, N., Colman, S., Cockram, D. B., and Kopple, J. D. An anti-inflammatory and antioxidant nutritional supplement for hypoalbuminemic hemodialysis patients: a pilot/feasibility study. Borage oil also boasts anti-inflammatory and antioxidant properties, which can help promote wound healing and repair your skin’s natural barrier (12). Medications that increase the break down of other medications by the liver (Cytochrome P450 3A4 (CYP3A4) inducers) interacts with BORAGE. The bright blue flowers are star-shaped. Borage is a plant. In traditional medicine, borage has been used to dilate blood vessels, act as a sedative, and treat seizures (5). Barre, D. E. and Holub, B. J. View abstract. Borage seed oil might slow blood clotting. © 2005 - 2019 WebMD LLC. Influence of formulas with borage oil or borage oil plus fish oil on the arachidonic acid status in premature infants. One of the interesting things about borage is that, … View abstract. Nutr Cancer 1995;24:33-45. . Thijs C, van Houwelingen A, Poorterman I, et al. Borage leaves and flowers were added to wine and lemon juice to make the popular English beverages claret cup and cool tankard. View abstract. J Nat Prod 1986;49:727-8. Borage oil should be diluted and applied topically. turmeric, echinacea, milk thistle, creatine, saw palmetto. J Am Diet.Assoc 2005;105(1):54-63. Marine and botanical lipids as immunomodulatory and therapeutic agents in the treatment of rheumatoid arthritis. Borage oil contains high amounts of gamma linolenic acid (GLA), a fatty acid that’s integral to the structure and function of your skin (12). Therefore, more research is needed to evaluate how borage extract may affect asthma and inflammation. Rothman D, DeLuca P, Zurier RB. Semin Liver Dis 2002;22:195-206. View abstract. Borage seed oil contains GLA (gamma linolenic acid). 2004;11(1):13-21. Enteral Nutrition in ARDS Study Group. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Borage oil is prized for its high gamma linoleic acid (GLA) content. How Long Does Coronavirus Live On Surfaces? Also known as starflower, borage is an herb notable for its vibrant purple flowers and medicinal properties. In medicinal use today it is limited, but the seeds are a source of linolenic acid. To be on the safe side, you should stop taking borage seed oil at least two weeks before surgery. Sign Up to Receive Our Free Coroanvirus Newsletter, Acute respiratory distress syndrome (ARDS). Kast RE. View abstract. Available at: https://www.ars-grin.gov/duke/. Lipids 1992;27(5):315-320. Borage supplements may be associated with mild side effects, including digestive issues like gas, bloating, and indigestion (14). What you eat can have a big effect on inflammation in your body. What Are the 7 Different Types of Eczema? Effects of linoleic acid and gamma-linolenic acid on the growth and metastasis of a human breast cancer cell line in nude mice and on its growth and invasive capacity in vitro. It has been used and may help as a treatment for itchy inflamed skin, wounds, eczema, rashes, arthritis and gout. View abstract. Ann.Nutr Metab 1994;38(1):40-47. The Am J Clin Nutr 2000;71:352S-6S. Because borage contains low concentrations of substances that have been associated with liver damage, it should not be used with drugs that could affect the liver, such as anabolic steroids, phenothiazine, or ketoconazole. Palombo, J. D., DeMichele, S. J., Boyce, P. J., Lydon, E. E., Liu, J. W., Huang, Y. S., Forse, R. A., Mizgerd, J. P., and Bistrian, B. R. Effect of short-term enteral feeding with eicosapentaenoic and gamma-linolenic acids on alveolar macrophage eicosanoid synthesis and bactericidal function in rats. It’s especially rich in gamma linoleic acid (GLA), which is an omega-6 fatty acid that has been shown to decrease inflammation (1). Ann Nutr Metab 2001;45:47-57. Larson KM, Roby MR, Stermitz FR. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Borage is a medicinal herb that has been associated with a number of powerful health benefits. Demmelmair, H., Feldl, F., Horvath, I., Niederland, T., Ruszinko, V., Raederstorff, D., De Min, C., Muggli, R., and Koletzko, B. Borage oil is an extract made from the seeds of the Borago officinalis plant.

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